TRPA1 Polyclonal Antibody, Invitrogen™

Catalog No.	Quantity
PIPA588615	100 μL

Catalog No. PIPA588615 Supplier Thermo Scientific Supplier No. PA588615

Description

Rabbit Polyclonal Antibody

Positive Samples: HeLa, Mouse heart; Cellular Location: Cell membrane, Multi-pass membrane protein Immunogen sequence: SPLLSIIQTF SMMLGDINYR ESFLEPYLRN ELAHPVLSFA QLVSFTIFVP IVLMNLLIGL AVGDIAEVQK HASLKRIAMQ VELHTSLEKK LPLWFLRKVD Q

TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. TRPA1 is a transformation -associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation. The structure of TRPA1 is highly related to both the protein ankyrin and transmembrane proteins. The specific function of TRPA1 has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.

Specifications

• Antigen: TRPA1
• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1.45 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
• Gene: Trpa1
• Gene Accession No.: O75762, Q6RI86, Q8BLA8
• Gene Alias: Anktm1, ankyrin-like with transmembrane domains 1, ankyrin-like with transmembrane domains protein 1, FEPS, ion channel, drTRPA1, nompC, transformation-sensitive protein p120, transient receptor potential A1, transient receptor potential ankyrin 1a, transient receptor potential cation channel subfamily A member 1, transient receptor potential cation channel subfamily A member 1a, transient receptor potential cation channel, subfamily A, member 1a, transient receptor potential cation channel subfamily A member 1-like, transient receptor potential cation channel, subfamily A, member 1, transient receptor potential cation channel, subfamily A, member 1 L homeolog, transient receptor potential cation channel, subfamily A, member 1a, TRPA1, TRPA-1, trpa1.L, trpa1a, TRPA1b, XELAEV_18003616mg
• Gene Symbols: Trpa1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 900-1000 of human TRPA1 (NP_0156282)
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 277328, 312896, 8989
• Target Species: Human, Mouse, Rat
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG