Invitrogen™ TRPC5 Monoclonal Antibody (N67/15), APC

Catalog No.	Quantity
PIMA545477	100 μg

Catalog No. PIMA545477

Supplier: Invitrogen™ MA545477

Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45477 was sufficient for detection of TrpC5 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 110kDa.

TRPC5 belongs to the transient receptor family. TRPC5 is one of the seven mammalian TRPC (transient receptor potential channel) proteins. The TRPC5 protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC5 is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. TRPC5 also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). TRPC5 is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC5 is probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, or G-protein coupled receptors. TRPC5 has also been shown to be calcium-selective, and may also be activated by intracellular calcium store depletion. Diseases associated with TRPC5 include Hypertrophic Pyloric Stenosis and Pyloric Stenosis.

Specifications

• Antigen: TRPC5
• Applications: Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot, Immunocytochemistry, Microarray
• Classification: Monoclonal
• Clone: N67/15
• Concentration: 1 mg/mL
• Conjugate: APC
• Formulation: 2.48mM MES, 95.46mM phosphate with 2mM EDTA and no preservative; pH 7.4
• Gene: TRPC5
• Gene Accession No.: Q9QX29, Q9UL62
• Gene Alias: capacitative calcium entry channel 2; CCE2; hTRP5; Htrp-5; mtrp5; PPP1R159; protein phosphatase 1, regulatory subunit 159; short transient receptor potential channel 5; short transient receptor potential channel 5a; transient receptor potential cation channel, subfamily C, member 5a; transient receptor potential cation channel subfamily C member 5; transient receptor potential cation channel subfamily c member 5a; transient receptor potential cation channel, subfamily C, member 5; transient receptor potential cation channel, subfamily C, member 5a; transient receptor potential channel 5; transient receptor protein 5; TRP5; TRP-5; TrpC5; trpc5a; trp-related protein 5; Trrp5; vtransient receptor potential cation channel, subfamily C, member 5; wu:fi73f08
• Gene Symbols: TRPC5
• Host Species: Mouse
• Immunogen: Synthetic peptide amino acids 827-845 of human TrpC5 (also known as short transient receptor potential channel 5, and Htrp5).
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 140933, 22067, 7224
• Target Species: Human, Mouse, Rat
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b