Invitrogen™ TRPC5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110526

Catalog No. PIPA5110526

Description

Immunogen sequence: NLGCKKKTCH GPPLIRTMPR SSGAQGKSKA ESSSKRSFMG PSLKKLGLLF SKFNGHMSEP SSEPMYTISD GIVQQHCMWQ DIRYSQMEKG KAEACSQSEI N.

TRPC5 belongs to the transient receptor family. TRPC5 is one of the seven mammalian TRPC (transient receptor potential channel) proteins. The TRPC5 protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC5 is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. TRPC5 also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). TRPC5 is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC5 is probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, or G-protein coupled receptors. TRPC5 has also been shown to be calcium-selective, and may also be activated by intracellular calcium store depletion. Diseases associated with TRPC5 include Hypertrophic Pyloric Stenosis and Pyloric Stenosis.

Specifications

• Antigen: TRPC5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRPC5
• Gene Alias: capacitative calcium entry channel 2; CCE2; hTRP5; Htrp-5; mtrp5; PPP1R159; protein phosphatase 1, regulatory subunit 159; short transient receptor potential channel 5; short transient receptor potential channel 5a; transient receptor potential cation channel, subfamily C, member 5a; transient receptor potential cation channel subfamily C member 5; transient receptor potential cation channel subfamily c member 5a; transient receptor potential cation channel, subfamily C, member 5; transient receptor potential cation channel, subfamily C, member 5a; transient receptor potential channel 5; transient receptor protein 5; TRP5; TRP-5; TrpC5; trpc5a; trp-related protein 5; Trrp5; vtransient receptor potential cation channel, subfamily C, member 5; wu:fi73f08
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7224
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1.42 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q9UL62
• Gene Symbols: TRPC5
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 800-900 of human TRPC5 (NP_0366031).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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