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  5. Tocris Bioscience™ TRPC6-PAM-C20

Tocris Bioscience™ TRPC6-PAM-C20
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Catalog No. 687510
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68-751-0 10 mg
68-755-0 50 mg
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Description

Selective TRPC6 positive allosteric modulator

TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. Selectively activates TRPC6 over other TRP channels. Also activates TRPA1. Induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 (EC50 = 2.37 μM). Potentiates OAG (1-oleoyl-1-acetyl-sn-glycerol)-induced Ca2+ influx in human platelets, and enhances OAG-induced platelet aggregation.

Specifications

Chemical Name or Material 3-(3-,4-Dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)-2H-1-benzopyran-2-one
CAS 667427-75-0
Quantity 10 mg
Molecular Formula C22H21NO4
Purity 98%
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