Invitrogen™ TRPM2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5119946

Catalog No. PIPA5119946

Description

Positive Control: THP-1 cell lysate, PC-3 cell lysate, rat cerebellum tissue, human bone tissue, mouse brain tissue, SH-SY5Y. Subcellular Location: Lysosome, cell membrane, perikaryon, cell projection, cytoplasmic vesicle.

TRPM2 belongs to the ion transport protein family which includes Sodium, Potassium, Calcium ion channels. This family is characterized by proteins possessing 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. TRPM2 is activated by oxidative stress and confers susceptibility to cell death. Further, TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.

Specifications

• Antigen: TRPM2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRPM2
• Gene Alias: 9830168K16Rik; C79133; EC 3.6.1.13; EREG 1; EREG1; Estrogen-responsive element-associated gene 1 protein; KNP 3; KNP3; Long transient receptor potential channel 2; LTRPC 2; LTRPC2; LTrpC-2; MGC133383; NUDT9H; NUDT9L1; null; transient receptor potential cation channel subfamily M member 2; transient receptor potential cation channel, subfamily M, member 2; transient receptor potential channel 7; Transient receptor potential melastatin 2; transient receptor potential melastatin family 2; transient receptor protein 7; Trp7; TRPC 7; TRPC7; TRPM 2; Trpm2; Trpm2-predicted; Trrp7
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 28240, 294329, 7226
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: E9PTA2, O94759, Q91YD4
• Gene Symbols: TRPM2
• Immunogen: Synthetic peptide within mouse TRPM2 aa 100-150/1503 (Cytoplasmic).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG