TRPM4 Mouse anti-Human, Clone: OTI3C4, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF500370

Catalog No. 50-165-9449

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+, K+, Cs+, Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.

Specifications

• Antigen: TRPM4
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: TRPM4
• Gene Alias: LTrpC4, PFHB1B, TRPM4B, hTRPM4
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54795
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI3C4
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q8TD43
• Gene Symbols: TRPM4
• Immunogen: Full-length protein expressed in 293T cell transfected with human TRPM4 expression vector
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1