TRPM4 Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS9051R

Catalog No. 50-198-8782

Description

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+, K+, Cs+, Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.

Specifications

• Antigen: TRPM4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRPM4
• Gene Alias: 1110030C19Rik; AW047689; Calcium-activated non-selective cation channel 1; H LTrpC-4; hTRPM4; Long transient receptor potential channel 4; LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 4; Ltrpc4; LTrpC-4; melastatin like 2 protein; Melastatin-4; Melastatin-like 2; MLS2s; PFHB1B; Transient receptor potential cation channel subfamily M member 4; transient receptor potential cation channel, subfamily M, member 4; transient receptor potential ion channel melastatin subgroup member 4; TRPM4; TRPM4B
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 54795
• Content And Storage: -20°C
• Form: Liquid

• Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: Q8TD43
• Gene Symbols: TRPM4
• Immunogen: KLH conjugated synthetic peptide derived from human TRPM4.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG