TRPM8 Mouse anti-Human, Clone: OTI7A11, lyophilized, TrueMAB™

Catalog No.	Quantity
50-167-0536	100 μg

Catalog No. 50-167-0536 Supplier OriGene Supplier No. CF811228

Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. TRPM8 has an expression pattern within normal human tissues that is mostly restricted to prostate epithelial cells. TRPM8 mRNA expression is at moderate levels in normal prostate tissue and appears to be elevated in prostate cancer. Notably, TRPM8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding TRPM8 were hardly detected or not detected in the corresponding normal human tissues.

Specifications

• Antigen: TRPM8
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI7A11
• Conjugate: Unconjugated
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene: TRPM8
• Gene Accession No.: Q7Z2W7
• Gene Alias: LTRPC6, LTrpC-6, TRPP8, trp-p8
• Gene Symbols: TRPM8
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-300 of human TRPM8 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 79054
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1