Invitrogen™ TRPM8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA14282

Catalog No. PA14282

Description

PA1-4282 detects the Trp-p8 protein in human samples. PA1-4282 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~125 kDa protein representing Trp-p8 in transfected COS cells. PA1-4282 immunizing peptide corresponds to amino acid residues 278-292 and the C terminus sequence of the human Trp-p8 protein.

TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. TRPM8 has an expression pattern within normal human tissues that is mostly restricted to prostate epithelial cells. TRPM8 mRNA expression is at moderate levels in normal prostate tissue and appears to be elevated in prostate cancer. Notably, TRPM8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding TRPM8 were hardly detected or not detected in the corresponding normal human tissues.

Specifications

• Antigen: TRPM8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRPM8
• Gene Alias: CMR1; Cold menthol receptor 1; cold/menthol receptor 1; long transient receptor potential channel 6; LTRPC6; LTrpC-6; MGC2849; short form of the TRPM8 cationic channel; transient receptor melastatin 8 variant 1; transient receptor melastatin 8 variant 2; transient receptor potential cation channel subfamily M member 8; transient receptor potential cation channel, subfamily M, member 8; transient receptor potential p8; transient receptor potential subfamily M member 8; transient receptor potential-p8; TRP ion channel TRPM8; Trpm8; Trpp8; trp-p8
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79054
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q7Z2W7
• Gene Symbols: TRPM8
• Immunogen: Synthetic peptide: R(278) N Q L E K Y I S E R T I Q D(292) and synthetic peptide to the C terminus: (1090) N D L K G L L K E I A N K I K(1104).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG