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Invitrogen™ TRPM8 Polyclonal Antibody
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Catalog No. PIPA146239
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100 μg
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Catalog No. Quantity
PIPA146239 100 μg
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Catalog No. PIPA146239 Supplier Invitrogen™ Supplier No. PA146239
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Description

Rabbit Polyclonal Antibody

Suggested positive control: antigen standard for TRPM8 (transient overexpression lysate). Immunogen sequence: RNQLEKYISE RTIQD & NDLKGLLKEI ANKIK.

TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. TRPM8 has an expression pattern within normal human tissues that is mostly restricted to prostate epithelial cells. TRPM8 mRNA expression is at moderate levels in normal prostate tissue and appears to be elevated in prostate cancer. Notably, TRPM8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding TRPM8 were hardly detected or not detected in the corresponding normal human tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRPM8
Applications ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TRPM8
Gene Accession No. Q7Z2W7, Q8R4D5
Gene Alias CMR1; Cold menthol receptor 1; cold/menthol receptor 1; long transient receptor potential channel 6; LTRPC6; LTrpC-6; MGC2849; short form of the TRPM8 cationic channel; transient receptor melastatin 8 variant 1; transient receptor melastatin 8 variant 2; transient receptor potential cation channel subfamily M member 8; transient receptor potential cation channel, subfamily M, member 8; transient receptor potential p8; transient receptor potential subfamily M member 8; transient receptor potential-p8; TRP ion channel TRPM8; Trpm8; Trpp8; trp-p8
Gene Symbols TRPM8
Host Species Rabbit
Immunogen Synthetic peptides made to residues 278-292 and the C-terminus sequence of the human trp-p8 protein.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 171382, 79054
Target Species Human, Mouse, Drosophila
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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