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Invitrogen™ TRPV4 Polyclonal Antibody
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Catalog No. PIPA541066
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100 μL
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PIPA541066 100 μL
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Catalog No. PIPA541066 Supplier Invitrogen™ Supplier No. PA541066
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Description

Rabbit Polyclonal Antibody

Peptide sequence: RVDEVNWSHW NQNLGIINED PGKNETYQYY GFSHTVGRLR RDRWSSVVPR Sequence homology: Cow: 93%; Dog: 86%; Guinea Pig: 86%; Human: 100%; Mouse: 86%; Pig: 93%; Rabbit: 100%; Rat: 93%.

TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a cation-selective channel, activated in response to systemic osmotic pressure. Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. TRPV4 is a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The TRPV4 protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in the TRPV4 gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Diseases associated with TRPV4 include Metatropic Dysplasia and Spondylometaphyseal Dysplasia, Kozlowski Type. Multiple transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRPV4
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene Trpv4
Gene Accession No. Q9ERZ8, Q9HBA0
Gene Alias 0610033B08Rik; BCYM3; CMT2C; HMSN2C; LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 4; OSM9-like transient receptor potential channel 4; osm-9-like TRP channel 4; osmosensitive transient receptor potential channel 4; Otrpc4; SMAL; SPSMA; SSQTL1; Transient receptor potential cation channel subfamily V member 4; transient receptor potential cation channel, subfamily 5, member 4; transient receptor potential cation channel, subfamily V, member 4; transient receptor potential protein 12; Trp12; Trpv4; trpv4 channel; Vanilloi; vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; vanilloid receptor-related osmotically activated channel; vanilloid receptor-related osmotically activated channel (Vroac); vanilloid receptor-related osmotically activated channel protein; vanilloid receptor-related osmotically-activated channel; Vrl2; VRL-2; VROAC; VR-OAC; wu:fp52e02
Gene Symbols Trpv4
Host Species Rabbit
Immunogen Synthetic peptide directed towards the middle region of human TRPV4.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 59341, 66026
Target Species Human, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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