Invitrogen™ TRPV4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114478

Catalog No. PIPA5114478

Description

Positive controls that may be used include: SK-N-SH Cell Lysate, Human Lung Tissue Slide.

TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a cation-selective channel, activated in response to systemic osmotic pressure. Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. TRPV4 is a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The TRPV4 protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in the TRPV4 gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Diseases associated with TRPV4 include Metatropic Dysplasia and Spondylometaphyseal Dysplasia, Kozlowski Type. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: TRPV4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Trpv4
• Gene Alias: 0610033B08Rik; BCYM3; CMT2C; HMSN2C; LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 4; OSM9-like transient receptor potential channel 4; osm-9-like TRP channel 4; osmosensitive transient receptor potential channel 4; Otrpc4; SMAL; SPSMA; SSQTL1; Transient receptor potential cation channel subfamily V member 4; transient receptor potential cation channel, subfamily 5, member 4; transient receptor potential cation channel, subfamily V, member 4; transient receptor potential protein 12; Trp12; Trpv4; trpv4 channel; Vanilloi; vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; vanilloid receptor-related osmotically activated channel; vanilloid receptor-related osmotically activated channel (Vroac); vanilloid receptor-related osmotically activated channel protein; vanilloid receptor-related osmotically-activated channel; Vrl2; VRL-2; VROAC; VR-OAC; wu:fp52e02
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 59341
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q9HBA0
• Gene Symbols: Trpv4
• Immunogen: TRPV4 antibody was raised against an 18 amino acid peptide near the center of human TRPV4. The immunogen is located within amino acids 380 - 430 of TRPV4.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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