Invitrogen™ TRPV6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5144631

Catalog No. FEPA5144631

Description

Positive control: SW480 cell lysate, SK-Br-3 cell lysate, HepG2, HT-29, rat testis tissue, human kidney tissue, mouse colon tissue, human placenta tissue. Predicted band size: 87 kDa Subcellular Location: Cell membrane, Membrane.

Calcium-permeable channels, such as TRPV6, participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA). Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with BSPRY. Interacts with calmodulin.

Specifications

• Antigen: TRPV6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRPV6
• Gene Alias: ABP/ZF; Alu-binding protein with zinc finger domain; Cac; Calcium transport protein 1; calcium transporter-like protein; CAT; CaT1; CATL; CaT-L; CaT-like; ecac; ECaC; CaT; ECAC2; epithelial apical membrane calcium transporter/channel CaT1; epithelial calcium channel; epithelial calcium channel 2; HSA277909; ion channel; LP6728; matt-und-schlapp; mus; osmosensitive transient receptor potential channel 3; Otrpc3; transient receptor potential cation channel subfamily V member 6; transient receptor potential cation channel, subfamily 5, member 6; transient receptor potential cation channel, subfamily V, member 6; transient receptor potential vanilloid 5-6; trpv5-6; TRPV6; trpv6 protein; ZFAB
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114246, 55503, 64177
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q91WD2, Q9H1D0, Q9R186
• Gene Symbols: TRPV6
• Immunogen: Synthetic peptide corresponding to C terminal of Human TRPV6 aa 716-765/765.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG