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TRPV6 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA564070
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PIPA564070 100 μL
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Catalog No. PIPA564070 Supplier Thermo Scientific Supplier No. PA564070

Description

Rabbit Polyclonal Antibody

Immunogen sequence: SPHLSLPMPS VSRSTSRSSA NWERLRQGTL RRDLRGIINR GLEDGESWEY Q Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 80%.

Calcium-permeable channels, such as TRPV6, participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA). Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with BSPRY. Interacts with calmodulin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRPV6
Applications Immunohistochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TRPV6
Gene Accession No. Q9H1D0
Gene Alias ABP/ZF; Alu-binding protein with zinc finger domain; Cac; Calcium transport protein 1; calcium transporter-like protein; CAT; CaT1; CATL; CaT-L; CaT-like; ecac; ECaC; CaT; ECAC2; epithelial apical membrane calcium transporter/channel CaT1; epithelial calcium channel; epithelial calcium channel 2; HSA277909; ion channel; LP6728; matt-und-schlapp; mus; osmosensitive transient receptor potential channel 3; Otrpc3; transient receptor potential cation channel subfamily V member 6; transient receptor potential cation channel, subfamily 5, member 6; transient receptor potential cation channel, subfamily V, member 6; transient receptor potential vanilloid 5-6; trpv5-6; TRPV6; trpv6 protein; ZFAB
Gene Symbols TRPV6
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TRPV6
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55503
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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