Invitrogen™ TRRAP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120661

Catalog No. PIPA5120661

Description

Positive test controls include: HeLa, Rat testis. Immunogen sequence: PNATDYWTFR KMFTIQLALI GFAEFVLHLN RLNPEMLQIA QDTGKLNVAY FRFDINDATG DLDANRPVPF RLTPNISEFL TTIGVSGPLT ASMIAVARCF AQPNFKVDGI LKTVLRDEII AWHKKTQEDT SSPLSAAGQP ENMDSQQLVS LVQKAVTAIM TRLHNLAQFE GGESKVNTLV AAANSLDNLC RMDPAWHPWL.

TRRAP is an adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. TRRAP plays a central role in MYC transcription activation, and also participates in cell transformation by MYC is required for p53/TP53-, E2F1- and E2F4-mediated transcription activation and is also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. TRRAP probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation, however, it is probably not required in the steps following histone acetylation in processes of transcription activation. TRRAP may be required for the mitotic checkpoint and normal cell cycle progression. TRRAP is a component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Specifications

• Antigen: TRRAP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRRAP
• Gene Alias: 350/400 kDa PCAF-associated factor; AI481500; OTTHUMP00000197294; OTTHUMP00000197295; PAF350/400; PAF400; STAF40; Tra1; Tra1 homolog; transactivation/transformation-domain associated protein; transformation/transcription domain associated protein; transformation/transcription domain-associated protein; TR-AP; TRRAP
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 288471, 8295
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.92 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q9Y4A5
• Gene Symbols: TRRAP
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 3660-3859 of TRRAP (NP_001231509.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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