Invitrogen™ TrxR1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534685

Catalog No. PIPA534685

Description

Recommended positive controls: HepG2. Predicted reactivity: Mouse (87%), Rat (87%), Dog (89%), Pig (89%), Rabbit (92%), Chicken (81%), Rhesus Monkey (99%), Chimpanzee (99%), Bovine (90%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.

Specifications

• Antigen: TrxR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TXNRD1
• Gene Alias: gene associated with retinoic and IFN-induced mortality 12 protein; gene associated with retinoic and interferon-induced mortality 12 protein; GRIM12; GRIM-12; KDRF; KM-102-derived reductase-like factor; MGC9145; NADPH-dependent thioredoxin reductase; oxidoreductase; selenoprotein oxidoreductase; testis tissue sperm-binding protein Li 46a; thioredoxin reductase 1; thioredoxin reductase 1, cytoplasmic; thioredoxin reductase GRIM-12; thioredoxin reductase TR1; TR; TR alpha; TR1; Trxr1; TXNR; Txnrd1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 50493, 7296
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q16881, Q9JMH6
• Gene Symbols: TXNRD1
• Immunogen: Recombinant fragment corresponding to a region within amino acids 69 and 313 of TrxR1 (Uniprot ID#Q16881).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG