Invitrogen™ TrxR2 Recombinant Rabbit Monoclonal Antibody (4O1K0)

Catalog No.	Quantity
PIMA535730	100 μL

Catalog No. PIMA535730 Supplier Invitrogen™ Supplier No. MA535730

Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: MAAMAVALRG LGGRFRWRTQ AVAGGVRGAA RGAAAGQRDY DLLVVGGGSG GLACAKEAAQ LGRKVAVVDY VEPSPQGTRW GLGGTCVNVG CIPKKLMHQA.

The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide-disulfide oxidoreductases. All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) but distinctively with a C-terminal extension containing a catalytically active penultimate selenocysteine (SeCys) residue in the conserved sequence (-Gly-Cys-SeCys-Gly). TrxR is homodimeric protein in which each monomer includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to C-terminal SeCys-containing redox center, which then reduces the substrate like thioredoxin. The members of TrxR family are 55-58 kilodalton in molecular size and composed of three isoforms including cytosolic TrxR1, mitochondrial TrxR2, and TrxR3, known as Trx and GSSG reductase (TGR). TrxR plays a key role in protection of cells against oxidative stress and redox-regulatory mechanism of transcription factors and various biological phenomena.

Specifications

• Antigen: TrxR2
• Applications: ELISA, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 4O1K0
• Concentration: 0.79 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol, 0.05% BSA and 0.02% sodium azide; pH 7.3
• Gene: TXNRD2
• Gene Accession No.: Q9JLT4, Q9NNW7, Q9Z0J5
• Gene Alias: AA118373; ESTM573010; KIAA1652; Selenoprotein Z; SelZ; TGR; thioredoxin reductase 2; thioredoxin reductase 2, mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; thioredoxin reductase TR3; TR; TR beta; TR3; TR-BETA; Trxr2; Trxrd2; TXNRD2
• Gene Symbols: TXNRD2
• Host Species: Rabbit
• Immunogen: Synthetic peptide.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10587, 26462, 50551
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG