Invitrogen™ Trypsin 2 Monoclonal Antibody (410322)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524148

Catalog No. PIMA524148

Description

This antibody does not cross-react with recombinant human (rh) Trypsin 1 or rhTrypsin 3. This antibody recognizes both the pro and mature forms of rhTrypsin 2. Reconstitute at 0.5 mg/mL in sterile PBS.

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: Trypsin 2
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: P07478
• Gene Symbols: PRSS2
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Trypsin 2/PRSS2 Ala16-Ser247.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunoprecipitation, Western Blot
• Clone: 410322
• Conjugate: Unconjugated
• Gene: PRSS2
• Gene Alias: anionic trypsin; anionic trypsin II; Anionic trypsin-2; anionic trypsinogen; EC 3.4.21; EC 3.4.21.4; MGC111183; MGC120174; MGC120175; pancreatic anionic trypsinogen; pancreatic trypsin 2; pancreatic trypsin II; pretrypsinogen II; protease serine 2 preproprotein; protease, serine 2; protease, serine, 2; protease, serine, 2 (trypsin 2); PRSS2; Ptryss2; Serine protease 2; Ta; Tesp4; Try2; TRY8; TRYP; TRYP2; TRYP8; trypsin 2; trypsin II; trypsin Trypsin II; Trypsin-2; trypsinogen 2; trypsinogen 20; trypsinogen anionic precursor
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 5645
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized