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Invitrogen™ Trypsin 2 Monoclonal Antibody (410322)
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Catalog No. PIMA524148
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100 μg
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PIMA524148 100 μg
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Catalog No. PIMA524148 Supplier Invitrogen™ Supplier No. MA524148
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Description

Mouse Monoclonal Antibody

This antibody does not cross-react with recombinant human (rh) Trypsin 1 or rhTrypsin 3. This antibody recognizes both the pro and mature forms of rhTrypsin 2. Reconstitute at 0.5 mg/mL in sterile PBS.

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Trypsin 2
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 410322
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene PRSS2
Gene Accession No. P07478
Gene Alias anionic trypsin; anionic trypsin II; Anionic trypsin-2; anionic trypsinogen; EC 3.4.21; EC 3.4.21.4; MGC111183; MGC120174; MGC120175; pancreatic anionic trypsinogen; pancreatic trypsin 2; pancreatic trypsin II; pretrypsinogen II; protease serine 2 preproprotein; protease, serine 2; protease, serine, 2; protease, serine, 2 (trypsin 2); PRSS2; Ptryss2; Serine protease 2; Ta; Tesp4; Try2; TRY8; TRYP; TRYP2; TRYP8; trypsin 2; trypsin II; trypsin Trypsin II; Trypsin-2; trypsinogen 2; trypsinogen 20; trypsinogen anionic precursor
Gene Symbols PRSS2
Host Species Mouse
Immunogen Mouse myeloma cell line NS0-derived recombinant human Trypsin 2/PRSS2 Ala16-Ser247.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5645
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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