Trypsinogen Polyclonal Antibody, HRP, Rockland™

Rabbit Polyclonal Antibody

Supplier:  Rockland Immunochemicals 20043800100

Catalog No. 50-199-1130

Description

Store vial at 4°C prior to restoration. For extended storage aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Anti-TRYPSINOGEN (RABBIT) Antibody is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Peroxidase, anti-Rabbit Serum as well as purified and partially purified Trypsinogen [Bovine Pancreas]. Cross reactivity against Trypsinogen from other tissues and species may occur but have not been specifically determined.

Trypsin is a 24 kDa enzyme of the serine proteinase family. It is produced in the pancreas as an inactive precursor, trypsinogen, but the active enzyme is located in the gastrointestinal tract where it degrades proteins to large peptides. Trypsin prefers lysine and arginine residues. One of the substrates for trypsin is chymotrypsinogen which is cleaved to produce active chymotrypsin. High levels of immunoreactive trypsin in the bloodstream can indicate pancreatic malfunction and this indicator is used to screene for and diagnose Cystic Fibrosis.

Specifications

• Antigen: Trypsinogen
• Classification: Polyclonal
• Conjugate: HRP
• Gene: PRSS2
• Gene Symbols: PRSS1, PRSS2
• Immunogen: Trypsinogen [Bovine Pancreas]
• Regulatory Status: RUO
• Gene ID (Entrez): 282603, 615026
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Lyophilized

• Applications: ELISA, Immunoprecipitation, Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.02M potassium phosphate with 0.15M NaCl, 10 mg/mL BSA and 0.01% gentamicin sulfate; pH 7.2
• Gene Alias: Alpha-trypsin chain 1; Alpha-trypsin chain 2; Anionic trypsin I; Anionic trypsin II; Anionic trypsin-1; Anionic trypsin-2; Anionic trypsinogen; Beta-trypsin; Cationic trypsinogen; digestive zymogen; MGC120175; MGC149362; nonfunctional trypsin 1; pancreatic trypsin 1; pancreatic trypsin 2; pancreatic trypsin II; Pretrypsinogen I; Pretrypsinogen II; Protease Serine 1; protease serine 2 preproprotein; protease, serine 1; protease, serine 1 (trypsin 1); protease, serine 2; protease, serine, 1; protease, serine, 1 (trypsin 1); protease, serine, 2; protease, serine, 2 (trypsin 2); Prss1; PRSS2; PTRYI; Ptryss2; RATPTRYI; Serine protease 1; Serine protease 2; Ta; TCR V beta 4.1; Tesp4; TRP1; TRY1; Try-1; TRY2; TRY4; TRY8; Trygn16; TRYP; TRYP1; TRYP2; TRYP8; trypsin 1; trypsin 2; Trypsin I; Trypsin II; Trypsin-1; Trypsin-2; trypsinogen 1; trypsinogen 16; trypsinogen 2; trypsinogen 20; trypsinogen A
• Host Species: Rabbit
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Bovine
• Product Type: Antibody