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Invitrogen™ TSC1 Recombinant Rabbit Monoclonal Antibody (6Q10T10)
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Catalog No. PIMA535652
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100 μL
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PIMA535652 100 μL
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Catalog No. PIMA535652 Supplier Invitrogen™ Supplier No. MA535652
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: TTMGEASASI PTTVGSLPSS KSFLGMKARE LFRNKSESQC DEDGMTSSLS ESLKTELGKD LGVEAKIPLN LDGPHPSPPT PDSVGQLHIM DYNETHHEHS.

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. A shorter 40 kDa isoform of TSC1 has been shown to exist but its function is unknown.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TSC1
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 6Q10T10
Concentration 0.49 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene TSC1
Gene Accession No. Q92574
Gene Alias hamartin; HGNC:12362; Kiaa0243; LAM; MGC86987; OTTHUMP00000022439; OTTHUMP00000198378; TSC; Tsc1; tuberous sclerosis 1; tuberous sclerosis 1 protein; Tuberous sclerosis 1 protein homolog; tumor suppressor
Gene Symbols TSC1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1065-1164 of human Hamartin (Q92574).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7248
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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