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TSC1 Mouse anti-Human, Clone: OTI2G3, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF801952

Encompass_Preferred

Catalog No. 50-166-5794


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Implicated as a tumor suppressor. May have a function in vesicular transport. Interaction between TSC1 and TSC2 may facilitate vesicular docking.Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex. TSC is an autosomal domit multi-system disorder that affects especially the brain, kidneys, heart, and skin. TSC is characterized by hamartomas (benign overgrowths predomitly of a cell or tissue type that occurs normally in the organ) and hamartias (developmental abnormalities of tissue combination). Clinical symptoms can range from benign hypopigmented macules of the skin to profound mental retardation with intractable seizures to premature death from a variety of disease-associated causes.Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.
Specifications

Specifications

TSC1
Monoclonal
Unconjugated
TSC1
LAM, TSC
Mouse
Affinity Chromatography
RUO
7248
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Western Blot
OTI2G3
PBS with 8% trehalose and no preservative; pH 7.3
Q92574
TSC1
Human recombit protein fragment corresponding to amino acids 836-1164 of human TSC1 produced in E.coli.
100 μg
Primary
Human
Antibody
IgG1
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