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Invitrogen™ TSC1 Polyclonal Antibody
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Catalog No. PIPA5119858
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100 μL
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PIPA5119858 100 μL
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Catalog No. PIPA5119858 Supplier Invitrogen™ Supplier No. PA5119858
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Description

Rabbit Polyclonal Antibody

Positive Control: LO2 cell lysate, 293 cell lysate, A431 cell lysate, mouse pancreas tissue lysate, rat brain tissue lysate, LOVO, rat heart tissue, human fetal skeletal muscle tissue, human placenta tissue, Hela cell lysates. Subcellular Location: Cytoplasm, Membrane.

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. A shorter 40 kDa isoform of TSC1 has been shown to exist but its function is unknown.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TSC1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene TSC1
Gene Accession No. Q92574, Q9EP53, Q9Z136
Gene Alias hamartin; HGNC:12362; Kiaa0243; LAM; MGC86987; OTTHUMP00000022439; OTTHUMP00000198378; TSC; Tsc1; tuberous sclerosis 1; tuberous sclerosis 1 protein; Tuberous sclerosis 1 protein homolog; tumor suppressor
Gene Symbols TSC1
Host Species Rabbit
Immunogen Recombinant protein within human Hamartin aa 400-600.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 60445, 64930, 7248
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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