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Invitrogen™ TSCOT Polyclonal Antibody
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Catalog No. PIPA554147
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100 μL
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PIPA554147 100 μL
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Catalog No. PIPA554147 Supplier Invitrogen™ Supplier No. PA554147
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KVPESVAKPS QELPAVDTVS GTVGTYRTLD PDQLDQQYAV GHPPSPGKAK PH Highest antigen sequence identity to the following orthologs: Mouse - 60%, Rat - 62%.

The TSCOT gene, known as the Thymic Stromal Co-transporter, plays a crucial role in the gene expression regulation within thymic epithelial cells, essential for T cell development. It encodes a protein that bears weak homology to bacterial 12 transmembrane co-transporters. Research indicates that TSCOT is predominantly expressed in thymic tissues, although low levels of expression are detectable in other epithelial tissues such as skin and lungs. The gene has been co-analyzed with Foxn1 and Hoxa3, highlighting its significant role in organogenesis. Studies utilizing competitive reverse transcription-polymerase chain reaction (RT-PCR) have mapped TSCOT to specific genomic regions, verifying its expression in a tissue and cell-type specific manner. The introduction of a neoantigen into TSCOT-expressing cells demonstrates its capability to mediate antigen-specific T cell tolerance, offering potential applications in immunological therapies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TSCOT
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SLC46A2
Gene Accession No. Q9BY10
Gene Alias 5430429N04Rik; Ly110; putative thymic stromal co-transporter TSCOT; SLC46A2; Solute carrier family 46 member 2; solute carrier family 46, member 2; thymic stromal co-transporter; thymic stromal cotransporter homolog; Thymic stromal cotransporter protein; TSCOT; TSO-1C12
Gene Symbols SLC46A2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TSCOT. Recombinant protein control fragment (Product #RP-92924).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57864
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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