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Invitrogen™ TSCOT Polyclonal Antibody
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Catalog No. PIPA590509
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100 μL
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PIPA590509 100 μL
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Catalog No. PIPA590509 Supplier Invitrogen™ Supplier No. PA590509
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MSPEVTCPRR GHLPRFHPRT WVEPVVASSQ VAASLYDAGL LLVVKASYGT GGSSNHSASP SPRGALEDQQ QRAISNFYII YNLVVGLSPL LSAYGLGWLS DRYHRKISIC; Positive Samples: LO2, Raji, MCF7, Mouse heart, Mouse brain, Mouse spleen; Cellular Location: Cell membrane, Multi-pass membrane protein.

The TSCOT gene, known as the Thymic Stromal Co-transporter, plays a crucial role in the gene expression regulation within thymic epithelial cells, essential for T cell development. It encodes a protein that bears weak homology to bacterial 12 transmembrane co-transporters. Research indicates that TSCOT is predominantly expressed in thymic tissues, although low levels of expression are detectable in other epithelial tissues such as skin and lungs. The gene has been co-analyzed with Foxn1 and Hoxa3, highlighting its significant role in organogenesis. Studies utilizing competitive reverse transcription-polymerase chain reaction (RT-PCR) have mapped TSCOT to specific genomic regions, verifying its expression in a tissue and cell-type specific manner. The introduction of a neoantigen into TSCOT-expressing cells demonstrates its capability to mediate antigen-specific T cell tolerance, offering potential applications in immunological therapies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TSCOT
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.47 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene SLC46A2
Gene Accession No. Q8CA03, Q9BY10
Gene Alias 5430429N04Rik; Ly110; putative thymic stromal co-transporter TSCOT; SLC46A2; Solute carrier family 46 member 2; solute carrier family 46, member 2; thymic stromal co-transporter; thymic stromal cotransporter homolog; Thymic stromal cotransporter protein; TSCOT; TSO-1C12
Gene Symbols SLC46A2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human SLC46A2 (NP_1490403).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 30936, 57864
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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