Invitrogen™ TSEN15 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA569842

Catalog No. PIPA569842

Description

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%.

Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.

Specifications

• Antigen: TSEN15
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tsen15
• Gene Alias: 5730449L18Rik; AL023077; C16H1ORF19; C1orf19; HsSEN15; PCH2F; RGD1308584; sen15; SEN15 homolog; tRNA splicing endonuclease 15 homolog; tRNA splicing endonuclease 15 homolog (S. cerevisiae); tRNA splicing endonuclease subunit 15; tRNA-intron endonuclease Sen15; tRNA-splicing endonuclease subunit Sen15; Tsen15; TSEN15 tRNA splicing endonuclease subunit; Unknown (protein for MGC:127982)
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 66637
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q8R3W5
• Gene Symbols: Tsen15
• Immunogen: synthetic peptide directed towards the middle region of human TSEN15 (aa 109-158).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov