Invitrogen™ TSEN15 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556087

Catalog No. PIPA556087

Description

Immunogen sequence: EERGDSEPTP GCSGLGPDGV RGFGDGGGAP SWAPEDAWMG THPKYLEMME LDIGDATHVY VAFLVYLDLM ESK Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 84%.

Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.

Specifications

• Antigen: TSEN15
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tsen15
• Gene Alias: 5730449L18Rik; AL023077; C16H1ORF19; C1orf19; HsSEN15; PCH2F; RGD1308584; sen15; SEN15 homolog; tRNA splicing endonuclease 15 homolog; tRNA splicing endonuclease 15 homolog (S. cerevisiae); tRNA splicing endonuclease subunit 15; tRNA-intron endonuclease Sen15; tRNA-splicing endonuclease subunit Sen15; Tsen15; TSEN15 tRNA splicing endonuclease subunit; Unknown (protein for MGC:127982)
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116461
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8WW01
• Gene Symbols: Tsen15
• Immunogen: Recombinant protein corresponding to Human TSEN15. Recombinant protein control fragment (Product #RP-94557).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov