Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Invitrogen™ TSEN2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA576281
Description
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre- mRNA 3'-end processing factors, establishing a link between pre- tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.
Specifications
TSEN2 | |
Polyclonal | |
Unconjugated | |
Tsen2 | |
AU067695; HsSen2; PCH2B; RGD1309946; SEN2; SEN2L; tRNA splicing endonuclease 2 homolog (S. cerevisiae); tRNA splicing endonuclease subunit 2; tRNA-intron endonuclease Sen2; tRNA-intron nuclease 2; tRNA-splicing endonuclease subunit Sen2; Tsen2; TSEN2 tRNA splicing endonuclease subunit | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
312649, 381802, 80746 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry, Western Blot, Western Blot | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.2 | |
Q5M954, Q6P7W5, Q8NCE0 | |
Tsen2 | |
Recombinant fusion protein of human TSEN2. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction