Invitrogen™ TSHZ3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5116843

Catalog No. PIPA5116843

Description

Positive Samples: U-87MG, HepG2 Immunogen sequence: DLTKGKSDKG CSLGSVLLSP TSTAPATSSS TVTTAKTSAV VSFMSNSPLR ENALSDISDM LKNLTESHTS KSSTPSSISE KSDIDGATLE EAEESTPAQK.

The Teashirt zinc finger homeobox (TSHZ) family comprise a family of evolutionarily conserved transcription factors that, in Drosophila, are active in specific body parts for patterning, but whose function in vertebrates is less clear. In mice, the known three TSHZ proteins are expressed in distinct patterns in the developing and adult brain, suggesting that they play a role in the establishment of regional identity and specification of cell types within the brain. Both TSHZ3 and TSHZ1 have been found to interact with FE65, an adapter protein that binds to the amyloid protein precursor (APP) in neurons. Together with SET, a component of the inhibitor of acetyl transferase, and histone deacetylases, these proteins formed a gene-silencing complex whose target includes caspase-4. Recent experiments have also suggested this family of proteins may be involved in carcinogenesis.

Specifications

• Antigen: TSHZ3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tshz3
• Gene Alias: A630038G13Rik; Kiaa1474; mKIAA1474; teashirt 3; teashirt homolog 3; teashirt zinc finger family member 3; teashirt zinc finger homeobox 3; teashirt3; Tsh3; Tshz3; Zfp537; zinc finger protein 537; ZNF537
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 243931, 57616
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.09 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q63HK5, Q8CGV9
• Gene Symbols: Tshz3
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 791-890 of human TSHZ3 (NP_0659072).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG