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Invitrogen™ TSLP Monoclonal Antibody (152640)

Catalog No. PIMA523779
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PIMA523779 500 μg
PIMA523875 100 μg
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Catalog No. PIMA523779 Supplier Invitrogen™ Supplier No. MA523779
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Description

Rat Monoclonal Antibody

In Western blots, this antibody does not cross-react with recombinant mouse IL-7 or recombinant human TSLP. Reconstitute at 0.5 mg/mL in sterile PBS.

TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c (+) dendritic cells, naive CD4 (+), and CD8 (+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory T cells and maintenance of peripheral CD4 (+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. It is expressed in heart, liver and prostate.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TSLP
Applications ELISA, Western Blot
Classification Monoclonal
Clone 152640
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene TSLP
Gene Accession No. Q9JIE6
Gene Alias Thymic stroma-derived lymphopoietin; thymic stromal lymphopoietin; TSLP
Gene Symbols TSLP
Host Species Rat
Immunogen Sf 21-derived recombinant mouse TSLP Tyr20-Glu140.
Purification Method Protein A/G
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 53603
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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