Invitrogen™ TSLP Monoclonal Antibody (152640)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA523779

Catalog No. PIMA523779

Description

In Western blots, this antibody does not cross-react with recombinant mouse IL-7 or recombinant human TSLP. Reconstitute at 0.5 mg/mL in sterile PBS.

TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c (+) dendritic cells, naive CD4 (+), and CD8 (+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory T cells and maintenance of peripheral CD4 (+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. It is expressed in heart, liver and prostate.

Specifications

• Antigen: TSLP
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q9JIE6
• Gene Symbols: TSLP
• Immunogen: Sf 21-derived recombinant mouse TSLP Tyr20-Glu140.
• Quantity: 500 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Western Blot
• Clone: 152640
• Conjugate: Unconjugated
• Gene: TSLP
• Gene Alias: Thymic stroma-derived lymphopoietin; thymic stromal lymphopoietin; TSLP
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 53603
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized