Invitrogen™ TSLP Polyclonal Antibody

Catalog No.	Quantity
PIPA546975	100 μg

Catalog No. PIPA546975 Supplier Invitrogen™ Supplier No. PA546975

Description

Sheep Polyclonal Antibody

In sandwich ELISAs, less than 0.1% cross-reactivity with recombinant mouse TSLP and recombinant human TSLP R is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c (+) dendritic cells, naive CD4 (+), and CD8 (+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory T cells and maintenance of peripheral CD4 (+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. It is expressed in heart, liver and prostate.

Specifications

• Antigen: TSLP
• Applications: ELISA, Neutralization, Western Blot
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative
• Gene: TSLP
• Gene Accession No.: Q969D9
• Gene Alias: Thymic stroma-derived lymphopoietin; thymic stromal lymphopoietin; TSLP
• Gene Symbols: TSLP
• Host Species: Sheep
• Immunogen: E. coli-derived recombinant human TSLP Tyr29-Gln159.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 85480
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG

Safety and Handling

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