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PeproTech TSLP Polyclonal Antibody, Biotin, PeproTech®, Invitrogen™

Catalog No. 502718561
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Catalog No. Quantity
50-271-8561 500 μg
500P258BT50 50 μg
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Catalog No. 50-271-8561 Supplier PeproTech Supplier No. 500P258BT500UG
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Description

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: MYDFTNCDFE KIKAAYLSTI SKDLITYMSG TKSTEFNNTV SCSNRPHCLT EIQSLTFNPTAGCASLAKEM FAMKTKAALA IWCPGYSETQ INATQAMKKR RKRKVTTNKC LEQVSQLQGLWRRFNRPLLK QQ. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human TSLP. Anti-Human TSLP-specific antibody was purified by affinity chromatography and then biotinylated. Sandwich ELISA: To detect hTSLP by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.25-1.0 μg/mL of this antibody is required. This biotinylated polyclonal antibody, in conjunction with PeproTech Polyclonal Anti-Human TSLP (500-P258) as a capture antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant hTSLP. Western Blot: To detect hTSLP by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant hTSLP is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions. 500-P258BT-1MG will be provided as 2 x 500 μg

TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c (+) dendritic cells, naive CD4 (+), and CD8 (+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory T cells and maintenance of peripheral CD4 (+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. It is expressed in heart, liver and prostate.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TSLP
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.1-1.0 mg/mL
Conjugate Biotin
Formulation PBS with no preservative
Gene TSLP
Gene Accession No. Q969D9
Gene Alias Thymic stroma-derived lymphopoietin; thymic stromal lymphopoietin; TSLP
Gene Symbols TSLP
Host Species Rabbit
Immunogen E.coli-derived, 15.0 kDa Recombinant Human TSLP.
Purification Method Antigen affinity chromatography
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 85480
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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