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TSLP Receptor, Mouse anti-Human, Clone: 1A6, Millipore Sigma™

Catalog No. MABF2042100 Shop All MilliporeSigma Products
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Catalog No. MABF2042100 Supplier MilliporeSigma Supplier No. MABF2042100UG
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Description

Mouse Monoclonal Antibody

Anti-TSLP Receptor, clone 1A6, Cat. No. MABF2042, is a mouse monoclonal antibody that detects TSLP receptor and has been tested for use in Flow Cytometry.

Cytokine receptor-like factor 2 (UniProt: Q9HC73; also known as Cytokine receptor-like 2, IL-XR, Thymic stromal lymphopoietin protein receptor, TSLP receptor) is encoded by the CRLF2 (also known as CRL2, ILXR, TSLPR) gene (Gene ID: 64109) in human. TSLP receptor is a single-pass type I membrane protein that serves as a receptor for thymic stromal lymphopoietin. It forms a functional complex with TSLP and IL7R to stimulate cell proliferation via activation of STAT3 and STAT5. It is primarily expressed in dendrites and monocytes and its expression has also been reported in heart, skeletal muscle, kidney and liver. Its levels are up-regulated in activated peripheral monocytes and THP-1 cells. TSLP receptor is synthesized with a signal peptide (aa 1-21), which is subsequently cleaved off in the mature form. It contains an extracellular domain (aa 23-231), a transmembrane domain (aa 232-252), and a cytoplasmic domain (aa 253-371). It also has a WSXWS motif (aa 200-204) that is essential for proper protein folding and efficient intracellular transport and cell-surface binding. In addition, its Box 1 motif (aa 261-269) is reported to be important for its association with JAKs. Three isoforms of TSLP receptors have been described that are produced by alternative splicing.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TSLP Receptor
Applications Flow Cytometry
Classification Monoclonal
Clone 1A6
Conjugate Unconjugated
Formulation Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Alias Cytokine receptor-like factor 2;Cytokine receptor-like 2;IL-XR;Thymic stromal lymphopoietin protein receptor;TSLPR
Gene Symbols CRLF2;CRL2;ILXR;TSLPR
Host Species Mouse
Immunogen Fc-fusion protein of ectodomain region of human TSLP receptor protein.
Purification Method Protein G purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Inflammation & Immunology
Primary or Secondary Primary
Gene ID (Entrez) NP_071431.2
Test Specificity Clone 1A6 specifically detects human TSLP receptor protein. It targets an epitope with in the extracellular domain.
Target Species Human
Content And Storage Stable for 1 year at 2-8°C from date of receipt.
Form Purified
Isotype IgG2a λ
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