TSLP Receptor, Mouse anti-Human, Clone: 1A6, Millipore Sigma™

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma MABF2042100UG

Catalog No. MABF2042100

Description

Anti-TSLP Receptor, clone 1A6, Cat. No. MABF2042, is a mouse monoclonal antibody that detects TSLP receptor and has been tested for use in Flow Cytometry.

Cytokine receptor-like factor 2 (UniProt: Q9HC73; also known as Cytokine receptor-like 2, IL-XR, Thymic stromal lymphopoietin protein receptor, TSLP receptor) is encoded by the CRLF2 (also known as CRL2, ILXR, TSLPR) gene (Gene ID: 64109) in human. TSLP receptor is a single-pass type I membrane protein that serves as a receptor for thymic stromal lymphopoietin. It forms a functional complex with TSLP and IL7R to stimulate cell proliferation via activation of STAT3 and STAT5. It is primarily expressed in dendrites and monocytes and its expression has also been reported in heart, skeletal muscle, kidney and liver. Its levels are up-regulated in activated peripheral monocytes and THP-1 cells. TSLP receptor is synthesized with a signal peptide (aa 1-21), which is subsequently cleaved off in the mature form. It contains an extracellular domain (aa 23-231), a transmembrane domain (aa 232-252), and a cytoplasmic domain (aa 253-371). It also has a WSXWS motif (aa 200-204) that is essential for proper protein folding and efficient intracellular transport and cell-surface binding. In addition, its Box 1 motif (aa 261-269) is reported to be important for its association with JAKs. Three isoforms of TSLP receptors have been described that are produced by alternative splicing.

Specifications

• Antigen: TSLP Receptor
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene Alias: Cytokine receptor-like factor 2;Cytokine receptor-like 2;IL-XR;Thymic stromal lymphopoietin protein receptor;TSLPR
• Host Species: Mouse
• Purification Method: Protein G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Clone 1A6 specifically detects human TSLP receptor protein. It targets an epitope with in the extracellular domain.
• Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
• Isotype: IgG2a λ

• Applications: Flow Cytometry
• Clone: 1A6
• Formulation: Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
• Gene Symbols: CRLF2;CRL2;ILXR;TSLPR
• Immunogen: Fc-fusion protein of ectodomain region of human TSLP receptor protein.
• Quantity: 100 μg
• Research Discipline: Inflammation & Immunology
• Gene ID (Entrez): NP_071431.2
• Target Species: Human
• Form: Purified