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TSLP Receptor, Rat anti-Mouse, Clone: 22H9, Millipore Sigma™

Catalog No. MABF1966100 Shop All MilliporeSigma Products
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MABF1966100 100 μg
MABF196625 25 μg
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Catalog No. MABF1966100 Supplier MilliporeSigma Supplier No. MABF1966100UG
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Description

Rat Monoclonal Antibody

Anti-TSLP Receptor, clone 22H9, Cat. No. MABF1966, is a rat monoclonal antibody that detects TSLP receptor and has been tested for use in Flow Cytometry.

Cytokine receptor-like factor 2 (UniProt: Q8CII9; also known as Cytokine receptor-like molecule 2, CRLM-2, Thymic stromal lymphopoietin protein receptor, TSLP receptor, Type I cytokine receptor delta 1) is encoded by the Crlf2 (also known as rlm2, Tpte2, Tslpr) gene (Gene ID: 57914) in murine species. TSLP receptor is a single-pass type I membrane protein that serves as a receptor for thymic stromal lymphopoietin. It is expressed in liver, lung, testis, heart, brain, spleen, thymus, and bone marrow. Higher expression levels are observed in progenitors and myeloid cells. Its levels can be up-regulated in the myeloid 32D cell line by granulocyte colony-stimulating factor. TSLP receptor forms a functional complex with TSLP and IL7R, which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. It has also been implicated in the development of the hematopoietic system. It is synthesized with a signal peptide (aa 1-19), which is subsequently cleaved off to generate the mature form. The mature form contains an extracellular domain (aa 20-232), a transmembrane domain (aa 233-253), and a cytoplasmic domain (aa 254-359). It contains WSXWS motif (aa 201-205), which is essential for proper protein folding and efficient intracellular transport and cell-surface binding. It also has a Box 1 motif (aa 262-270) that is required for JAK interaction and activation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TSLP Receptor
Applications Flow Cytometry
Classification Monoclonal
Clone 22H9
Conjugate Unconjugated
Dilution Flow Cytometry Analysis: A representative lot detected TSLP receptor in Flow Cytometry applications (Bell, B.D., et. al. (2013). Nat Immunol. 14(4):364-71; Isaksen, D.E., et. al. (2002). J Immunol. 168(7):3288-94; Iseki, M., et. al. (2012). Int Immunol. 24(3):183-95; Kashiwagi, M., et. al. (2017). Nat Immunol. 18(3):334-343).
Formulation Purified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Alias Cytokine receptor-like factor 2;Cytokine receptor-like molecule 2;CRLM-2;Thymic stromal lymphopoietin protein receptor;Type I cytokine receptor delta 1
Gene Symbols Crlf2;rlm2;Tpte2;Tslpr
Host Species Rat
Immunogen His-tagged murine recombinant TSLP Receptor Protein.
Purification Method Protein G purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Inflammation & Immunology
Primary or Secondary Primary
Gene ID (Entrez) NP_001158207.1
Test Specificity Clone 22H9 is a rat monoclonal antibody that detects Thymic stromal lymphopoietin protein receptor (TSLPR) in murine species. It targets an epitope with in the extracellular domain.
Target Species Mouse
Content And Storage Stable for 1 year at 2-8°C from date of receipt.
Form Purified
Isotype IgG2a κ
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