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Invitrogen™ TSP50 Monoclonal Antibody (260606)
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Catalog No. PIMA523959
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100 μg
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Catalog No. Quantity
PIMA523959 100 μg
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Catalog No. PIMA523959 Supplier Invitrogen™ Supplier No. MA523959
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Description

Rat Monoclonal Antibody

In direct ELISAs and Western blots, no cross-reactvity with recombinant mouse TSP50 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

Testes-specific protease 50 (TSP50) is a gene located within the chromosome region 3p21.31, primarily expressed in testicular tissue, and is homologous to serine proteases. However, TSP50 contains a distinctive catalytic triad where serine, a crucial catalytic residue, is replaced by threonine, allowing it to exhibit a novel protease activity. TSP50 is recognized for its role as a pro-oncogene, contributing significantly to cancer progression by promoting aerobic glycolysis, known as the Warburg effect, in hepatocellular carcinoma cells through interaction with pyruvate kinase M2 isoform (PKM2). This function underlines its involvement in cancer metabolism, as it attenuates colitis by regulating TGF-β signaling pathways. Furthermore, studies have linked TSP50 to cancer stem cell maintenance, driving stem-like properties in breast cancer cells, thereby facilitating tumor initiation and self-renewal capabilities. These characteristics highlight TSP50's potential as a target in therapeutic interventions for cancer treatment.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TSP50
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 260606
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene PRSS50
Gene Accession No. Q9UI38
Gene Alias 79H19C; Cancer/testis antigen 20; CT20; Probable threonine protease PRSS50; protease, serine 50; protease, serine, 50; PRSS50; Serine protease 50; testes specific protease 50; testes-specific protease 50; testicular tissue protein Li 210; testis-specific protease-like protein 50; Tsp50
Gene Symbols PRSS50
Host Species Rat
Immunogen Mouse myeloma cell line NS0-derived recombinant human TSP50 Ala40-Ala363 (predicted).
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29122
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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