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Invitrogen™ TSPO Monoclonal Antibody (CL13358)
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Catalog No. PIMA546545
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100 μL
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PIMA546545 100 μL
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Catalog No. PIMA546545 Supplier Invitrogen™ Supplier No. MA546545
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Description

Mouse Monoclonal Antibody

Highest antigen sequence indentity to the following orthologs: Rat - 75%, Mouse - 81%.

Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, where it mediates the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation. PBR is composed of three subunits, an isoquinoline binding site, a voltage-dependent anion channel and an adenine nucleotide carrier. PBR is genetically conserved from bacteria to humans and in humans is widely expressed in peripheral organs, whereas in the brain, it is sparse and located mainly in glial cells. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits the Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TSPO
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone CL13358
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Tspo
Gene Accession No. P30536
Gene Alias Benzodiazepin receptor (peripheral); benzodiazepine peripheral binding site; benzodiazepine receptor, peripheral; BPBS; BZRP; DBI; IBP; isoquinoline-binding protein; MBR; mDRC; mitochondrial benzodiazepine receptor; OTTHUMP00000028891; PBR; PBS; peripheral-type benzodiazepine receptor; pk18; PKBS; PTBR; Ptbzr; PTBZR02; RATPTBZR02; translocator protein; translocator protein (18kDa); TSPO; Tspo1
Gene Symbols Tspo
Host Species Mouse
Immunogen Synthetic Peptide.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 706
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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