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Invitrogen™ TSPO Polyclonal Antibody
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Catalog No. PIPA518565
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100 μg
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Catalog No. Quantity
PIPA518565 100 μg
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Catalog No. PIPA518565 Supplier Invitrogen™ Supplier No. PA518565
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Description

Goat Polyclonal Antibody

This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.

Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, where it mediates the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation. PBR is composed of three subunits, an isoquinoline binding site, a voltage-dependent anion channel and an adenine nucleotide carrier. PBR is genetically conserved from bacteria to humans and in humans is widely expressed in peripheral organs, whereas in the brain, it is sparse and located mainly in glial cells. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits the Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TSPO
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Tspo
Gene Accession No. P30536
Gene Alias Benzodiazepin receptor (peripheral); benzodiazepine peripheral binding site; benzodiazepine receptor, peripheral; BPBS; BZRP; DBI; IBP; isoquinoline-binding protein; MBR; mDRC; mitochondrial benzodiazepine receptor; OTTHUMP00000028891; PBR; PBS; peripheral-type benzodiazepine receptor; pk18; PKBS; PTBR; Ptbzr; PTBZR02; RATPTBZR02; translocator protein; translocator protein (18kDa); TSPO; Tspo1
Gene Symbols Tspo
Host Species Goat
Immunogen Synthetic peptide sequence (RDNHGWRGGRRLPE) corresponding to the C-terminus amino acids of TSPO (aa 156-169).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 706
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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