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Invitrogen™ TSPO Polyclonal Antibody
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Catalog No. PIPA590595
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100 μL
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PIPA590595 100 μL
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Catalog No. PIPA590595 Supplier Invitrogen™ Supplier No. PA590595
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MAPPWVPAMG FTLAPSLGCF VGSRFVHGEG LRWYAGLQKP SWHPPHWVLG; Positive Samples: Mouse testis; Cellular Location: Mitochondrion membrane, Multi-pass membrane protein.

Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, where it mediates the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation. PBR is composed of three subunits, an isoquinoline binding site, a voltage-dependent anion channel and an adenine nucleotide carrier. PBR is genetically conserved from bacteria to humans and in humans is widely expressed in peripheral organs, whereas in the brain, it is sparse and located mainly in glial cells. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits the Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TSPO
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.75 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Tspo
Gene Accession No. P50637
Gene Alias Benzodiazepin receptor (peripheral); benzodiazepine peripheral binding site; benzodiazepine receptor, peripheral; BPBS; BZRP; DBI; IBP; isoquinoline-binding protein; MBR; mDRC; mitochondrial benzodiazepine receptor; OTTHUMP00000028891; PBR; PBS; peripheral-type benzodiazepine receptor; pk18; PKBS; PTBR; Ptbzr; PTBZR02; RATPTBZR02; translocator protein; translocator protein (18kDa); TSPO; Tspo1
Gene Symbols Tspo
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-50 of human PBR/PBR/TSPO (NP_0007052).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12257
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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