Invitrogen™ TTBK2 Polyclonal Antibody

Catalog No.	Quantity
PA551265	100 μL

Catalog No. PA551265 Supplier Invitrogen™ Supplier No. PA551265

Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total TTBK2 protein.

Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.

Specifications

• Antigen: TTBK2
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 3 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene: TTBK2
• Gene Accession No.: Q6IQ55
• Gene Alias: 2610507N02Rik; AI326283; B930008N24Rik; Bby; KIAA0847; mKIAA0847; Protein bartleby; SCA11; tau tubulin kinase 1; tau tubulin kinase 2; tau-tubulin kinase 2; Ttbk; Ttbk1; TTBK2; TTK
• Gene Symbols: TTBK2
• Host Species: Rabbit
• Immunogen: Synthetic peptide of human TTBK2.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 146057
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG