Invitrogen™ TTBK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA568647

Catalog No. PIPA568647

Description

This target displays homology in the following species: Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%.

Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.

Specifications

• Antigen: TTBK2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TTBK2
• Gene Alias: 2610507N02Rik; AI326283; B930008N24Rik; Bby; KIAA0847; mKIAA0847; Protein bartleby; SCA11; tau tubulin kinase 1; tau tubulin kinase 2; tau-tubulin kinase 2; Ttbk; Ttbk1; TTBK2; TTK
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 140810
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q3UVR3
• Gene Symbols: TTBK2
• Immunogen: synthetic peptide directed towards the middle region of human TTBK2 (aa 270-319).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG