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Invitrogen™ TTBK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA568647

Catalog No. PIPA568647


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Description

Description

This target displays homology in the following species: Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%.

Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

TTBK2
Polyclonal
Unconjugated
TTBK2
2610507N02Rik; AI326283; B930008N24Rik; Bby; KIAA0847; mKIAA0847; Protein bartleby; SCA11; tau tubulin kinase 1; tau tubulin kinase 2; tau-tubulin kinase 2; Ttbk; Ttbk1; TTBK2; TTK
Rabbit
Affinity chromatography
RUO
140810
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot
0.5 mg/mL
PBS with 2% sucrose and 0.09% sodium azide
Q3UVR3
TTBK2
synthetic peptide directed towards the middle region of human TTBK2 (aa 270-319).
100 μL
Primary
Mouse
Antibody
IgG
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