Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Invitrogen™ TTBK2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA568647
Description
This target displays homology in the following species: Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%.
Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.
Specifications
TTBK2 | |
Polyclonal | |
Unconjugated | |
TTBK2 | |
2610507N02Rik; AI326283; B930008N24Rik; Bby; KIAA0847; mKIAA0847; Protein bartleby; SCA11; tau tubulin kinase 1; tau tubulin kinase 2; tau-tubulin kinase 2; Ttbk; Ttbk1; TTBK2; TTK | |
Rabbit | |
Affinity chromatography | |
RUO | |
140810 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Western Blot | |
0.5 mg/mL | |
PBS with 2% sucrose and 0.09% sodium azide | |
Q3UVR3 | |
TTBK2 | |
synthetic peptide directed towards the middle region of human TTBK2 (aa 270-319). | |
100 μL | |
Primary | |
Mouse | |
Antibody | |
IgG |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction