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Invitrogen™ TTC3 Polyclonal Antibody
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Catalog No. PIPA554942
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100 μL
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PIPA554942 100 μL
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Catalog No. PIPA554942 Supplier Invitrogen™ Supplier No. PA554942
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DCPHVDDCVF AAEFMSNDYV RVTQLYCDGV GVQYKDYIQS ERNLEFDICS IWCSKPISVL QDYCDAIKIN IFWPLLFQHQ NSSVISRLHP CVDANNSRAS EINLKKLQHL ELMEDIVDLA KKVANDS Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 77%.

E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (PubMed:20059950, PubMed:30696809). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (PubMed:20059950). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (PubMed:20059950). Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 (PubMed:30696809). Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK (PubMed:17488780, PubMed:24695496). Inhibits cell proliferation (PubMed:30203323). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen TTC3
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TTC3
Gene Accession No. P53804
Gene Alias DCRR1; E3 ubiquitin-protein ligase TTC3; Protein DCRR1; RING finger protein 105; RING-type E3 ubiquitin transferase TTC3; RNF105; tetratricopeptide repeat domain 3; tetratricopeptide repeat protein 3; TPR repeat protein 3; TPR repeat protein D; TPRD; TPRDIII; TTC3
Gene Symbols TTC3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TTC3. Recombinant protein control fragment (Product #RP-91795).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7267
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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