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Invitrogen™ TTC30A Polyclonal Antibody
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Catalog No. PIPA562620
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100 μL
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PIPA562620 100 μL
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Catalog No. PIPA562620 Supplier Invitrogen™ Supplier No. PA562620
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LSYNLALAYY SSRQYASALK HIAEIIERGI RQHPELGVGM TTEGFDVRSV GNTLVLHQTA LVEA Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 92%.

The TTC30A gene encodes for the Tetratricopeptide Repeat Domain 30A, which is part of the intraflagellar transport (IFT) complex B, critical for ciliary function. TTC30A and its paralog TTC30B are involved in the stability and functioning of the IFT complex. These proteins play a redundant role in maintaining cilia integrity, necessary for proper cellular signaling and homeostasis. Disruption of TTC30A, through CRISPR/Cas9 gene editing, has shown to impair ciliogenesis, leading to developmental defects such as limb malformations and polycystic kidney disease due to altered tubulin acetylation and ciliary transport. This highlights the importance of TTC30A in cellular and developmental processes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TTC30A
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TTC30A
Gene Accession No. Q86WT1
Gene Alias IFT70A; tetratricopeptide repeat domain 30A; tetratricopeptide repeat domain 30B; tetratricopeptide repeat protein 30A; TPR repeat protein 30A; TTC30A
Gene Symbols TTC30A
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TTC30B. Recombinant protein control fragment (Product #RP-104480).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 92104
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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