Invitrogen™ TTC40 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA558571

Catalog No. PIPA558571

Description

Immunogen sequence: VKALQKMCLH ELTVPVLQLG VLISDSVVGS KGLSDLYHLR LAHACSELKL REAAARHEEA VGQVCVSELE QASCR Highest antigen sequence identity to the following orthologs: Mouse - 63%, Rat - 29%.

The TTC40 gene, which stands for Tetratricopeptide repeat domain 40, is a member of the TPR protein family characterized by highly conserved motifs that facilitate protein-protein interactions. This gene plays a significant role in various cellular processes, including signal transduction and protein assembly. TTC40 has been identified as a novel methylated gene in nasopharyngeal carcinoma, where its expression is significantly reduced in tumor tissues due to hypermethylation. This epigenetic alteration suggests a potential role of TTC40 in tumorigenesis, possibly acting as a tumor suppressor. The decreased expression of TTC40 in cancerous tissues highlights its importance in maintaining cellular homeostasis and integrity.

Specifications

• Antigen: TTC40
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CFAP46
• Gene Alias: 9330101J02Rik; bA288G11.4; bA288G11.5; bB137A17.2; bB137A17.3; C10orf123; C10orf124; C10orf92; C10orf93; CFAP46; cilia and flagella associated protein 46; cilia- and flagella-associated protein 46; E030019B06Rik; Gm170; protein CFAP46; RGD1559985; similar to chromosome 10 open reading frame 92; tetratricopeptide repeat domain 40; tetratricopeptide repeat protein 40; TPR repeat-containing protein C10orf93; TTC40
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54777
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IYW2
• Gene Symbols: CFAP46
• Immunogen: Recombinant protein corresponding to Human TTC40. Recombinant protein control fragment (Product #RP-103677).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG