Invitrogen™ Nkx2.1 Recombinant Rabbit Monoclonal Antibody (RM373)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA533074

Catalog No. PIMA533074

Description

Specificity: reacts to human TTF1 (Thyroid transcription factor 1) (Homeobox protein Nkx-2.1). It may also react to mouse and rat TTF1, as predicted by immunogen homology. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: Nkx2.1
• Classification: Recombinant Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
• Gene Accession No.: P43699
• Gene Symbols: NKX2-1
• Immunogen: A peptide corresponding to the N-terminus of human TTF1 (Thyroid transcription factor 1) (Homeobox protein Nkx-2.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: RM373
• Conjugate: Unconjugated
• Gene: NKX2-1
• Gene Alias: AV026640; BCH; BHC; homeobox protein NK-2 homolog A; Homeobox protein Nkx-2.1; NK-2; NK2 homeobox 1; NK-2 homolog A; NKX2.1; Nkx-2.1; NKX2-1; NKX2A; NMTC1; RNA polymerase I transcription termination factor; T/EBP; TEBP; Thyroid nuclear factor 1; thyroid transcription factor 1; thyroid transcription factor 1 TTF-1 NK-2; thyroid transcription factor 1-like; thyroid-specific enhancer-binding protein; tinman; TITF1; TTF1; TTF-1
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 7080
• Content And Storage: -20°C
• Form: Liquid