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Invitrogen™ Nkx2.1 Recombinant Rabbit Monoclonal Antibody (RM373)
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Catalog No. PIMA533074
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PIMA533074 100 μL
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Catalog No. PIMA533074 Supplier Invitrogen™ Supplier No. MA533074
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: reacts to human TTF1 (Thyroid transcription factor 1) (Homeobox protein Nkx-2.1). It may also react to mouse and rat TTF1, as predicted by immunogen homology. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Nkx2.1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone RM373
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene NKX2-1
Gene Accession No. P43699
Gene Alias AV026640; BCH; BHC; homeobox protein NK-2 homolog A; Homeobox protein Nkx-2.1; NK-2; NK2 homeobox 1; NK-2 homolog A; NKX2.1; Nkx-2.1; NKX2-1; NKX2A; NMTC1; RNA polymerase I transcription termination factor; T/EBP; TEBP; Thyroid nuclear factor 1; thyroid transcription factor 1; thyroid transcription factor 1 TTF-1 NK-2; thyroid transcription factor 1-like; thyroid-specific enhancer-binding protein; tinman; TITF1; TTF1; TTF-1
Gene Symbols NKX2-1
Host Species Rabbit
Immunogen A peptide corresponding to the N-terminus of human TTF1 (Thyroid transcription factor 1) (Homeobox protein Nkx-2.1).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7080
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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