Invitrogen™ TTI1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA566987

Catalog No. PIPA566987

Description

Immunogen sequence: ERLDLGEGDLN KVADACLIYL SVKQPVKLQE AARSVFLHLM KVDPDSTWFL LNELYCPVQF TPPHPSLHPV QLHGASGQQN PYTT Highest antigen sequence identity to the following orthologs - mouse 85%, rat 83%.

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.

Specifications

• Antigen: TTI1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TTI1
• Gene Alias: 2610036D13Rik; AI449463; KIAA0406; Protein SMG10; SMG10; smg-10; smg-10 homolog, nonsense mediated mRNA decay factor; Tel two interacting protein 1; Tel2 interacting protein 1 homolog; TEL2-interacting protein 1 homolog; TELO2 interacting protein 1; TELO2-interacting protein 1 homolog; TTI1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9675
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O43156
• Gene Symbols: TTI1
• Immunogen: Recombinant Human TTI1. Recombinant protein control fragment (Product #RP-107631).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG