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Invitrogen™ TTLL10 Polyclonal Antibody
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Catalog No. PIPA531631
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100 μL
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PIPA531631 100 μL
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Catalog No. PIPA531631 Supplier Invitrogen™ Supplier No. PA531631
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7, NIH-3T3. Predicted reactivity: Mouse (82%), Rat (82%), Rhesus Monkey (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The TTLL10 gene encodes a protein that functions as a polyglycylase, playing an important role in the modification of nucleosome assembly protein 1 (NAP1) both in vivo and in vitro. This enzymatic activity is dependent on the presence of ATP and is abolished in mutant forms where the glutamate in the active site is replaced by valine. TTLL10 specifically incorporates glycine into recombinant NAP1 at Glu residues 359 and 360. This modification process likely has implications for protein interactions and cellular processes involving NAP1. Additionally, TTLL10 can perform tubulin glycylation when co-expressed with TTLL8, suggesting a complex interplay between these enzymes in cellular microtubule dynamics.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TTLL10
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene TTLL10
Gene Accession No. A4Q9F3, Q6ZVT0
Gene Alias 4833412E22Rik; 4930595O22Rik; AU022799; BC042775; Inactive polyglycylase TTLL10; protein polyglycylase TTLL10; Ttll10; Ttll5; tubulin tyrosine ligase like 10; tubulin tyrosine ligase-like family member 10; tubulin tyrosine ligase-like family, member 10; tubulin tyrosine ligase-like family, member 5; tubulin--tyrosine ligase-like protein 10
Gene Symbols TTLL10
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human TTLL10. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 254173, 330010
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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