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beta-3 Tubulin Mouse anti-Bovine, Human, Mouse, Rat, Clone: 2G10-TB3, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen 14451082

Catalog No. 50-112-2677


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Description

Description

Description: The 2G10 monoclonal antibody recognizes beta tubulin class III, a member of the large family of tubulins that are components of the microtubules of the cytoskeletal network. Beta tubulin class III expression is exclusively found in neuronal cells of adult mammals. Although expression has been mainly found in neuronal cells, during fetal development, transient expression has been documented in both glial and neuronal precursors localized to the subventricular zone. Identification of beta tubulin class III expression is useful as a structural marker for developing and mature neural cells. Given the high degree of conservation of this protein across species, the 2G10 clone is expected to recognize human, mouse, rat, and bovine beta tubulin class III. Applications Reported: This 2G10 antibody has been reported for use in immunoprecipitation, western blotting, immunohistochemical staining of frozen or formalin-fixed paraffin embedded tissue sections, and immunocytochemistry. Applications Tested: This 2G10 antibody has been tested by immunocytochemistry of fixed and permeabilized cells and can be used at less than or equal to 5 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 µm post-manufacturing filtered.

The betaIII-tubulin isoform is present domitly in cells of neuronal origin and it is one of the earliest markers of neuronal differentiation. It is regarded as a specific probe for the cells of neuronal origin as well as for the tumours originating from these cells. The betaIII-tubulin is most abundant in cells of neuronal origin, but was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues.
Specifications

Specifications

beta-3 Tubulin
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q9ERD7, Q13509, Q2T9S0, Q4QRB4
neuron specific beta III Tubulin
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Bovine, Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
2G10-TB3
Unconjugated
TUBB3
Liquid
Tubb3
IgG2a, kappa
100 μg
4° C
Primary
10381, 22152, 246118, 768070
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