Invitrogen™ TWA1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521785

Catalog No. PIPA521785

Description

Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji. Predicted reactivity: Mouse (99%), Rat (99%), Xenopus laevis (96%), Chicken (97%), Rhesus Monkey (100%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

TWA1 was identified through a two hybrid-associated protein screen with RanBPM. TWA1 is well conserved through evolution and is localized within the nucleus. It interacts with RanBP9 and comprises a protein complex with RanBPM and Muskelin. TWA1 was found to possess the LisH-CTLH motif which is detected in proteins involved in microtubule dynamics, cell migration, nucleokinesis and chromosome segregation. These functions overlap with functions suggested for the RanGTPase cycle. Recent findings suggested that there is an as yet uncovered function of the RanGTPase cycle.

Specifications

• Antigen: TWA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GID8
• Gene Alias: 2310003C23Rik; 4833420G11Rik; AI451474; Bwk1; BWK-1; Bwk1 leukemia-related; C20orf11; GID complex subunit 8; GID complex subunit 8 homolog; GID complex subunit 8 homolog (S. cerevisiae); GID8; Glucose-induced degradation protein 8 homolog; protein C20orf11; protein C20orf11 homolog; TWA1; two hybrid associated protein 1; two hybrid associated protein No. 1 with RanBPM; two hybrid-associated protein 1 with RanBPM
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 296466, 54994
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9NWU2
• Gene Symbols: GID8
• Immunogen: Recombinant protein encompassing a sequence within the center region of human C20orf11. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov