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Invitrogen™ TWEAK Monoclonal Antibody (CARL-1)
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Catalog No. PIMA528606
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100 μg
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Catalog No. Quantity
PIMA528606 100 μg
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Catalog No. PIMA528606 Supplier Invitrogen™ Supplier No. MA528606
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Description

Mouse Monoclonal Antibody

This antibody recognizes an extracellular epitope of CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to induce apoptosis weakly in many cell types.

TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TWEAK
Applications Flow Cytometry, Immunohistochemistry
Classification Monoclonal
Clone CARL-1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 15mM sodium azide; pH 8.0
Gene Tnfsf12
Gene Accession No. O43508
Gene Alias APO3 ligand; APO3/DR3 ligand; APO3L; Dr3l; Dr3lg; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 12; MGC129581; MGC20669; TNF superfamily member 12; TNF-related weak inducer of apoptosis; TNFSF12; TNLG4A; tumor necrosis factor (ligand) superfamily member 12; tumor necrosis factor (ligand) superfamily, member 12; tumor necrosis factor ligand 4A; tumor necrosis factor ligand superfamily member 12; Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form; tumor necrosis factor superfamily member 12; TWEAK; UNQ181/PRO207; zgc:153941
Gene Symbols Tnfsf12
Host Species Mouse
Immunogen human CD255-transfected 2PK-3 cells.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8742
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG3 κ
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