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Twist-1 Mouse anti-Human, Clone: 927403, R&D Systems™

Mouse Monoclonal Antibody

$136.85 - $319.00

Specifications

Antigen Twist-1
Formulation Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
Format Purified
Clone 927403
Applications CyTOF, Flow Cytometry, Western Blot
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
MAB6230SP View Documents R&D Systems
MAB6230SP
25 ug Each for $136.85
Add to cart
 
MAB6230 View Documents R&D Systems
MAB6230
100 ug Each for $319.00
Add to cart
 
Description

Description

Twist-1 (Twist-related protein 1; also H-Twist and bHLHa38) is a 25-27kDa class B member of the bHLH transcription factor family of proteins. It is widely expressed in embryo, and select adult cells such as white adipocytes. In fat, Twist-1 induces fatty acid oxidation via PGC-1α and CPT-1, and promotes MCP-1 and TNF-α secretion by adipocytes. In epithelium, Twist-1 dysregulation represses E-Cadherin and induces N-Cadherin expression, resulting in an epithelial-to-mesenchymal transition that can lead to cancer. Human Twist-1 is 202 amino acids (aa) in length. It contains a bHLH domain (aa 109-164) with an embedded DNA-binding motif. Twist-1 forms homodimers, and heterodimerizes with TCF3, HAND 1 and HAND 2. Two distinct mutations exist that may impact its dimerization pattern. There is one seven aa insertion after Ile135, and a second seven aa insertion after Pro139. A third unrelated variant shows a four Gly insert after Gly92. Full-length human Twist-1 shares 98% aa identity with mouse Twist-1.
Specifications

Specifications

Twist-1
Purified
CyTOF, Flow Cytometry, Western Blot
Mouse
Protein A or G purified from hybridoma culture supernatant
RUO
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
927403
Unconjugated
IgG1
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
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